Background/Aims: To assess the value of octreotide in the central of acute
bleeding esophageal varices, in a prospective randomized study.
Methodology: One hundred and ninety-seven patients admitted for variceal bl
eeding confirmed at endoscopy were recruited and divided into two groups: g
roup I (n=111) with endoscopic stigmata of recent bleeding; and group II (n
=86) with active bleeding at emergency endoscopy. Patients in group I were
randomized to receive a continuous infusion of octreotide (n=58) or emergen
cy sclerotherapy (n=53). Patients in group II were assigned to sclerotherap
y (n=42) or to sclerotherapy plus octreotide (n=44). At the end of the peri
od of study (48 hours), patients were submitted to sclerotherapy or band li
gation until variceal obliteration was achieved.
Results: In group I, octreotide was found to be as effective as sclerothera
py regarding hemostasis at 48 hours and on day 7 after the index bleeding e
pisode. Transfusion needs were not significantly different for the two trea
tment modalities. Ingroup II, the association of octreotide with sclerother
apy was significantly better than sclerotherapy alone either in controlling
acute active bleeding (P<0.001) or in achieving hemostasis at 48 hours (P<
0.01). Transfusion needs were significantly fewer in patients treated with
this therapeutic association as compared to sclerotherapy alone.
Conclusions: These results suggest that octreotide infusion is effective in
the treatment of variceal bleeding. In patients with recent bleeding, octr
eotide infusion is as effective as emergency sclerotherapy. In active varic
eal bleeding, it is a valuable adjuvant treatment in association with : eme
rgency sclerotherapy.