Regulated cutaneous gene delivery: The skin as a bioreactor

Authors
Cao, TY Wang, XJ Roop, DR
Citation
Ty. Cao et al., Regulated cutaneous gene delivery: The skin as a bioreactor, HUM GENE TH, 11(16), 2000, pp. 2297-2300
Citations number
27
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN GENE THERAPY
ISSN journal
10430342 → ACNP
Volume
11
Issue
16
Year of publication
2000
Pages
2297 - 2300
Database
ISI
SICI code
1043-0342(20001101)11:16<2297:RCGDTS>2.0.ZU;2-N
Abstract
Epidermal keratinocytes can secrete polypeptides into the bloodstream, and they can be easily expanded in culture and genetically modified. It is thus possible to use epidermal keratinocytes for the systemic delivery of trans gene products. Here we review the development of epidermal secretory system s, from cultured keratinocytes to skin grafts and transgenic mouse models. We also discuss a gene-switch approach for regulated cutaneous gene deliver y.