Associations between indoor CO2 concentrations and sick building syndrome symptoms in US office buildings: An analysis of the 1994-1996 BASE study data

Higher indoor concentrations of air pollutants due, in part, to lower venti lation rates are a potential cause of sick building syndrome (SBS) symptoms in office workers. The indoor carbon dioxide (CO2) concentration is an app roximate surrogate for indoor concentrations of other occupant-generated po llutants and for ventilation rate per occupant. Using multivariate logistic regression (MLR) analyses, we evaluated the relationship between indoor CO 2 concentrations and SBS symptoms in occupants from a probability sample of 41 U.S. office buildings. Two CO2 metrics were constructed: average workda y indoor minus average outdoor CO2 (dCO(2), range 6-418 ppm), and maximum i ndoor 1-h moving average CO2 minus outdoor CO2 concentrations (dCO(2)MAX). MLR analyses quantified dCO(2)/SBS symptom associations, adjusting for pers onal and environmental factors. A dose-response relationship (p<0.05) with odds ratios per 100 ppm dCO(2) ranging from 1.2 to 1.5 for sore throat, nos e/sinus, tight chest, and wheezing was observed. The dCO(2)MAX/SBS regressi on results were similar.