Optimism, distress, and immunologic status in HIV-infected gay men following Hurricane Andrew

This study investigated how dispositional optimism relates to psychological and immunologic status in 40 HIV-infected gay men residing in areas of Sou th Florida hard hit by Hurricane Andrew. In the months following the storm, participants' levers of psychological distress (hurricane-related and over all distress) and antibody titers to several herpesviruses (Herpes Simplex Virus-2, Epstein-Barr Virus [EBV], Cytomegalovirus, and Human Herpes Virus- 6 [HHV-6]) were measured. Overall, participants had elevated mean levels of hurricane-specific and general distress. Higher levels of optimism were re lated to lower levels of depression, overall distress, and hurricane-specif ic posttraumatic stress disorder symptoms. After controlling for nonspecifi c polyclonal B cell activation, greater optimism was also associated with l ower levels of circulating antibodies to EBV and HHV-6, suggesting better c ellular immunologic control over these viruses among optimists. Regression analyses showed that the relation between optimism and lower EBV titers was partially mediated by the lower depression levels experienced by optimists .