Mullerian duct regression is first apparent in male pouch young of the
tammar wallaby (Macropus eugenii) 6-7 days after birth and, as in eut
herian mammals, is characterised by a condensation of the periductal m
esenchyme into a whorl around the ductal epithelial cells. A decrease
in the density of the extracellular matrix was observed in the region
of the whorl. In contrast to eutherian mammals no changes were observe
d in the mean outer diameter of the Mullerian duct during the early st
ages of regression. The time at which these mesenchymal changes occur
corresponds to the period of Mullerian inhibiting substance secretion
in the postnatal tammar testis.