It is demonstrated that sugars can be determined with high sensitivity by h
igh-performance liquid chromatography (HPLC) with amperometric detection us
ing domestic instruments. Optimal conditions of the detection of catecholam
ines were selected; obtained detection limits provide the determination of
these compounds in biological fluids. Conditions of the simultaneous separa
tion of most familiar narcotics by HPLC on one column with high precision a
nd low detection limit were optimized.