Objective: The purpose of this study was to assess the feasibility of expos
ing wounds during low-level laser therapy (LLLT) by transillumination of th
e wound dressings. Background Data: LLLT has been associated with accelerat
ed wound healing in chronic ulcers, The usual approach is to remove wound d
ressings prior to exposure and to treat three to five times weekly. Frequen
t change of wound dressings is time consuming and costly; it disrupts the h
ealing process, increases the risk of wound infection, and may be traumatic
for the patient. Methods: A double integrating sphere setup was employed t
o quantify the diffuse transmittance and reflectance of various wound dress
ings. Differences in transmittance for large area sources and point sources
were demonstrated through the use of a diode laser and an incoherent light
source. Results: There were a number of gels and membrane style wound dres
sings with diffuse transmittance of more than 50%, Hence, for these dressin
gs the prescribed radiant exposure to the wound surface could be achieved b
y increasing the exposure duration, while maintaining reasonable overall tr
eatment times. Conclusions: Although LLLT by transillumination of wound dre
ssings is feasible for a variety of wound dressings without significant com
mitments in additional treatment time, the specific transmission of product
s not included in this study needs to be determined at the intended treatme
nt wavelength. A transillumination approach may facilitate a faster rate of
wound healing than LLLT applied to exposed wounds by reducing trauma and t
he risk of infection.