M. Ramaseshan et al., Solid phase combinatorial synthesis of a library of macro-heterocycles andrelated acyclic compounds, J COMB CHEM, 2(6), 2000, pp. 615-623
A solid phase synthesis of macrolactones from three building blocks and in
eight steps is described. The synthesis which is carried out on the DHP res
in includes Mitsunobu and DIC couplings. The macrocyclization occurs by SN2
displacement of an allylic chloride by a malonate anion. The synthetic met
hodology is suitable for the synthesis of arrays of macrocycles as well as
linear compounds.