Polymer-supported tetrafluorophenol: A new activated resin for chemical library synthesis

Authors
Salvino, JM Kumar, NV Orton, E Airey, J Kiesow, T Crawford, K Mathew, R Krolikowski, P Drew, M Engers, D Krolikowski, D Herpin, T Gardyan, M McGeehan, G Labaudiniere, R
Citation
Jm. Salvino et al., Polymer-supported tetrafluorophenol: A new activated resin for chemical library synthesis, J COMB CHEM, 2(6), 2000, pp. 691-697
Citations number
15
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF COMBINATORIAL CHEMISTRY
ISSN journal
15204766 → ACNP
Volume
2
Issue
6
Year of publication
2000
Pages
691 - 697
Database
ISI
SICI code
1520-4766(200011/12)2:6<691:PTANAR>2.0.ZU;2-5
Abstract
A new tetrafluorophenol activated resin that facilitates the use of F-19 NM R to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophi les including primary and secondary amines, and anilines. This new activate d resin methodology provides a powerful tool for pure single-compound libra ry synthesis.