Metastatic calcification of the cardiac conduction system with heart block: An under-reported entity in chronic renal failure patients

Citation
Pa. Isotalo et al., Metastatic calcification of the cardiac conduction system with heart block: An under-reported entity in chronic renal failure patients, J FOREN SCI, 45(6), 2000, pp. 1335-1338
Citations number
19
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
JOURNAL OF FORENSIC SCIENCES
ISSN journal
00221198 → ACNP
Volume
45
Issue
6
Year of publication
2000
Pages
1335 - 1338
Database
ISI
SICI code
0022-1198(200011)45:6<1335:MCOTCC>2.0.ZU;2-U
Abstract
Systemic metastatic calcification is a common complication of chronic renal failure. Cardiac involvement is particularly ominous, especially when the cardiac conduction system is affected. Conduction defects, arrhythmias, and sudden death have all been reported with conduction system calcification; however, these are relatively under-reported or unrecognized causes of card iac morbidity and mortality. We describe a 40-year-old man with Von Hippel- Lindau disease who had been maintained on hemodialysis for two years follow ing bilateral nephrectomies for renal cell, carcinoma. The patient presente d with symptomatic complete heart block that had progressed from Mobitz typ e I atrioventricular block. Two months later, while being internally paced, the patient died unexpectedly after a complicated hospital admission. Post mortem revealed extensive vascular, myocardial, and conduction system calci fication. Conduction system calcification may cause sudden death in chronic renal failure patients during hospital admission, or unexpectedly while th e patient is in the community. Knowledge of this condition is necessary to detect it, as the conduction system is not routinely examined. A routine ab breviated conduction system examination is warranted for patients with syst emic metastatic calcification, especially if they have sudden death or a kn own history of heart block.