Myelin oligodendrocyte glycoprotein (MOG) polymorphisms and adrenoleukodystrophy

We describe four novel sequence variants in the Myelin Oligodendrocyte Glyc oprotein (MOG) gene. A total of six sequence variants of the MOG gene were identified in eleven out of 44 ALD patients investigated: G15A, CTC repeat in exon 1, Val142Leu, Val145Ile, 551+68A-->G and 551+77C-->T. Screening stu dies demonstrated that all these polymorphisms are present in 50 unaffected control male individuals of the same population and in the different pheno types of ALD patients, indicating that they do not contribute to phenotype variability in ALD (C) 2000 Elsevier Science B,V. All rights reserved.