QUANTITATIVE PROTON MAGNETIC-RESONANCE ANALYSIS OF RANITIDINE IN SOLID DOSAGE FORMS

Authors
OZDEN T UNGORMUS A TOSUN A ERSAN S
Citation
T. Ozden et al., QUANTITATIVE PROTON MAGNETIC-RESONANCE ANALYSIS OF RANITIDINE IN SOLID DOSAGE FORMS, Spectroscopy letters, 30(5), 1997, pp. 835-841
Citations number
11
Categorie Soggetti
Spectroscopy
Journal title
Spectroscopy letters → ACNP
ISSN journal
00387010
Volume
30
Issue
5
Year of publication
1997
Pages
835 - 841
Database
ISI
SICI code
0038-7010(1997)30:5<835:QPMAOR>2.0.ZU;2-W
Abstract
A rapid and specific proton magnetic resonance (PMR) spectroscopic met hod was developed for determining ranitidine hydrochloride in tablets. 2-Choloroacetophenon was used as the internal standard and DMSO-d(6) served as the PMR solvent. The concentration of drug per unit dose was calculated from the integration values for the resonance signals of r anitidine hydrochloride at 4.32 delta ppm and int. st. at 5.19 delta p pm. The method using commercial products gave comparable results to th ose obtained by the methods of UV spectroscopy and USP XXIII.