A rapid and specific proton magnetic resonance (PMR) spectroscopic met
hod was developed for determining ranitidine hydrochloride in tablets.
2-Choloroacetophenon was used as the internal standard and DMSO-d(6)
served as the PMR solvent. The concentration of drug per unit dose was
calculated from the integration values for the resonance signals of r
anitidine hydrochloride at 4.32 delta ppm and int. st. at 5.19 delta p
pm. The method using commercial products gave comparable results to th
ose obtained by the methods of UV spectroscopy and USP XXIII.