Protective effects of manganese against lipid peroxidation

The aim of this study was to investigate the effects of chronic, daily, 30- d administration of manganese chloride (MnCl2) to male Sprague-Dawley rats on lipid peroxidation in various tissues. Rats were intraperitoneally injec ted with MnCl2 (20 mg/kg) once daily for 30 consecutive days. The Mn accumu lated in liver, spleen, adrenal glands, heart, kidneys, lung, and testes. T his was associated with decreased lipid peroxidation in liver, spleen, and adrenal glands and a decrease in the levels of Fe in these tissues. In a se cond group of animals, Mn (20 mg/kg/d) and glutathione (GSH, 15 mg/kg/d) we re administered ip for 30 d. GSH counteracted the Mn-induced protective fal l in lipid peroxidation, but Fe levels remained lower in liver and spleen. Mn decreases lipid peroxidation in certain tissues, which may involve lower ing Fe content, but interaction with Fe is not the sole mechanism.