THE STATISTICAL-ANALYSIS OF NEONATAL TSH RESULTS FROM CONGENITAL HYPOTHYROIDISM SCREENING PROGRAMS PROVIDES A USEFUL TOOL FOR THE CHARACTERIZATION OF MODERATE IODINE DEFICIENCY REGIONS

TSH data from the congenital hypothyroidism screening program were ana lyzed in a mild to moderate iodine deficiency region. Neonatal TSH lev els were measured at day 4-5 of life in 22,384 infants (99% coverage; 51.1% males, 48.9% females). The cut off TSH value for recall was esta blished at 20 mu Ul/ml whole blood. TSH values >20 mu Ul/ml were exclu ded from further analysis of the data. The frequency distribution anal ysis showed that the median neonatal TSH level was 2 mu Ul/ml and the mode (28% of newborns) corresponded to neonatal TSH values <1 mu Ul/ml , TSH levels above 5 mu Ul/ml were observed in 14.4% children and the 97% cut off was 11 mu Ul/ml. When examined in relation to the areas of newborn origin, the individual 97% cut off values varied from 8 to 14 mu Ul/ml. Accordingly, the frequency of TSH levels above the 97% cut off value calculated for the entire newborn series (>11 mu Ul/ml) rang ed from 2.1% to 4.6%, A significant correlation was found between the frequency of neonatal TSH levels >11 mu Ul/ml and both goiter prevalen ce (r(2) = 0.88; p = 0.0019) and median urinary iodine excretion (r(2) = 0.86, p = 0.0077) observed in those areas for which epidemiological data were available (n = 7), The results indicate that neonatal TSH d ata from the congenital hypothyroidism screening programs can be used for monitoring mild to moderate iodine deficiency regions, (C) 1997, E ditrice Kurtis.