Cortical evoked potentials of the dorsal nerve of the clitoris and female sexual dysfunction in multiple sclerosis

Purpose: We evaluated whether disrupting genital central nervous system pat hways is associated with subjective reports of sexual dysfunction in women with multiple sclerosis. Materials and Methods: We performed pudendal somatosensory evoked potential testing in and had sexual questionnaires completed by 14 women with a mean age of 47 years who had multiple sclerosis. Results: The mean expanded disability status score was 5. All but 1 woman r eported the desire for sexual intercourse. There was a high rate of dissati sfaction with their sex life and all study participants had concomitant bla dder and bowel function problems. The most common sexual complaint was diff icult or no orgasm, which was statistically associated with abnormalities o r absence of 1 or both pudendal cortical evoked potentials. Fatigue and aro usal disorders were also common. Conclusions: Women with multiple sclerosis have a high self-reported rate o f sexual dysfunction, which decreases quality of life. Electrodiagnostic da ta imply that pudendal somatosensory innervation is necessary for normal fe male orgasmic function. More study is needed to confirm these findings.