BRAIN KINETICS OF (R)-[N-METHYL-C-11]KETAMINE AND (S)-[N-METHYL-C-11]KETAMINE IN THE RHESUS-MONKEY STUDIED BY POSITRON EMISSION TOMOGRAPHY (PET)

Authors
HARTVIG P VALTYSSON J ANTONI G WESTERBERG G LANGSTROM B MOBERG ER OYE I
Citation
P. Hartvig et al., BRAIN KINETICS OF (R)-[N-METHYL-C-11]KETAMINE AND (S)-[N-METHYL-C-11]KETAMINE IN THE RHESUS-MONKEY STUDIED BY POSITRON EMISSION TOMOGRAPHY (PET), Nuclear medicine and biology, 21(7), 1994, pp. 927-934
Citations number
24
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
21
Issue
7
Year of publication
1994
Pages
927 - 934
Database
ISI
SICI code
0969-8051(1994)21:7<927:BKO(A(>2.0.ZU;2-3
Abstract
The regional brain kinetics of the two enantiomers of the NMDA channel blocker ketamine radiolabelled with C-11 was studied in the Rhesus mo nkey by means of positron emission tomography (PET). The uptake in bra in areas which showed high radioactivities was blocked in a dose-depen dent manner for both C-11-labelled enantiomers with simultaneous doses of the respective unlabelled (S)- or (R)-ketamine, indicating specifi c binding. The binding in the striatum and cortical areas of (S)-[N-me thyl-C-11]ketamine was selective and displaceable by the (R)-enantiome r and by MK-801.