Potent, selective aminothiazolidinediones agonists of the human beta(3) adrenergic receptor

A cloned human beta (3) adrenergic receptor assay was used to identify pote nt and selective beta (3) agonists. The thiazolidinedione moiety has been i dentified as a new pharmacophore for the human beta (3) adrenergic receptor . The versatility of the thiazolidinedione pharmacophore was demonstrated i n both the arylethanolamine and phenylpropanolamine families of beta (3) ag onists, where potent and selective compounds have been synthesized. Thiazol idinedione 20, a potent and selective human beta (3) agonist, increased the rmogenesis and lowered plasma glucose levels in the db/db mice.