Methamphetamine-induced apoptosis is attenuated in the striata of copper-zinc superoxide dismutase transgenic mice

Authors
Deng, XL Cadet, JL
Citation
Xl. Deng et Jl. Cadet, Methamphetamine-induced apoptosis is attenuated in the striata of copper-zinc superoxide dismutase transgenic mice, MOL BRAIN R, 83(1-2), 2000, pp. 121-124
Citations number
24
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
83
Issue
1-2
Year of publication
2000
Pages
121 - 124
Database
ISI
SICI code
0169-328X(20001110)83:1-2<121:MAIAIT>2.0.ZU;2-A
Abstract
Administration of methamphetamine caused significant increases in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positi ve cells, in poly (ADP-ribose) polymerase (PARP) cleavage, as well as in ca spase-3 activity in the striata of C57BL/6J mice. In contrast, all these ef fects were markedly suppressed in the copper-zinc superoxide dismutase tran sgenic mice. These results indicate that superoxide radicals might be impor tant factors in METH-induced cell death. (C) 2000 Elsevier Science B.V. All rights reserved.