Correlation between inter-ictal regional cerebral blood flow and sphenoidal electrodes - recorded inter-ictal spikes in mesial temporal lobe epilepsy

Citation
M. Lemesle et al., Correlation between inter-ictal regional cerebral blood flow and sphenoidal electrodes - recorded inter-ictal spikes in mesial temporal lobe epilepsy, NEUROL RES, 22(7), 2000, pp. 674-678
Citations number
32
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROLOGICAL RESEARCH
ISSN journal
01616412 → ACNP
Volume
22
Issue
7
Year of publication
2000
Pages
674 - 678
Database
ISI
SICI code
0161-6412(200010)22:7<674:CBIRCB>2.0.ZU;2-A
Abstract
The objective of this study was to assess the reliability of the diagnosis of mesial temporal lobe epilepsy using EEG and sphenoidal electrodes. Inter -ictal 99 m Tc-HMPAO SPECT scans were registered in 21 patients with confir med mesial temporal lobe epilepsy identified by scalp EEG and sphenoidal el ectrodes. Visual and quantitative SPECT analysis was performed blind to EEG data. An asymmetry index (Al) was measured from the ratio of two symmetric al regions of interest A temporal lobe hypoperfusion was defined as an upta ke reduced by 5% with respect to the contralateral region. Inter-ictal SPEC T abnormalities were observed in 12 out of 21 patients (57%) from both visu al and quantitative analysis (focal hypoperfusion in 11 cases, focal hyperp erfusion in one case). In seven patients (33%) both visual and quantitative scintigraphy were normal. Abnormal Al was found in 11/15 patients with a h igh frequency of seizures and in 1/6 patients with a low frequency of seizu res. The major data is that the probability to have an abnormal SPECT is st atistically correlated to the frequency of the epileptic fits. The couple E EG recordings with sphenoidal electrodes and SPECT is sensitive and reliabl e in the diagnosis of mesial temporal lobe epilepsy.