A 15-year-old girl with features of Henoch-Schonlein purpura and brain infa
rct had a transient IgA antiphosphatidylethanolamine antibody (aPE) in her
serum and CSF that disappeared 5 months after presentation. Serum aPE is kn
own to be associated with thrombotic events. The authors found no aPE in th
e CSF of two control individuals or in the serum of two patients with activ
e Henoch-SchGnlein purpura without neurologic involvement. The patient may
represent a variant of antiphospholipid antibody syndrome.