Because of the recurrent nature of migraine, a major concern with pharmacol
ogic therapy is whether it will remain effective, safe, and tolerable over
the long term. The development of sumatriptan offered an improvement in mig
raine therapy, although concerns remain about chest symptoms associated wit
h this class of drugs. In early clinical trials, rizatriptan was shown to h
ave good bioavailability and favorable effects on quality of life. Long-ter
m extension trials ran for up to 12 months and compared rizatriptan with "u
sual care" (i.e., medications used for acute therapy). These studies showed
that the 10-mg rizatriptan dose was consistently superior to usual care wi
th regard to pain relief and complete pain relief(pain-free). Side effects
were generally mild and transient in all treatment groups. Nausea, dizzines
s, and somnolence were the most commonly reported adverse effects.