Dendritic cell-like immunoreactivity in the glomerulus of the olfactory bulb and olfactory nerves of mice

Dendritic cell-like immunoreactivity was examined in the mouse brain. The g lomerulus of the olfactory bulb and the olfactory nerves were stained by an tibodies against the dendritic cells, NLDC-145 and MIDC-8, while these stru ctures were not stained by antibodies against microglia or macrophages, F4/ 80, Mad or CD45. Immunoelectron microscopy showed that the immunoreaction f or NLDC-145 was localized to the sheath and presynaptic terminals of the ol factory nerves. These findings suggest that the sheath and presynaptic term inals of the primary olfactory nerves have some degree of the antigenicity in common with dendritic cells. NeuroReport 11:3573-3576 (C) 2000 Lippincot t Williams & Wilkins.