The mGlu(5) receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A(2A) receptors

Authors
Pintor, A Pezzola, A Reggio, R Quarta, D Popoli, P
Citation
A. Pintor et al., The mGlu(5) receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A(2A) receptors, NEUROREPORT, 11(16), 2000, pp. 3611-3614
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
11
Issue
16
Year of publication
2000
Pages
3611 - 3614
Database
ISI
SICI code
0959-4965(20001109)11:16<3611:TMRACS>2.0.ZU;2-7
Abstract
The intrastriatal perfusion of the selective metabotropic glutamate (mGlu)( 5) receptor agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG, 1000 muM) s ignificantly increased (similar to +100%, p < 0.05) glutamate extracellular levels with respect to basal values. The potentiating effect of CHPG was p revented by the selective mGlu(5) receptor antagonist 2-methyl-6(phenylethy nyl)-pyridine (MPEP, 250 <mu>M)) and by the adenosine A(2A) receptor antago nist SCH 58261 (2 mg/kg, i.p.). The results show that mGlu(5) receptors are involved in the regulation of striatal glutamate release and suggest an in volvement of adenosine A(2A) receptors in mGlu(5) receptor-mediated effects . NeuroReport 11:3611-3614 (C) 2000 Lippincott Williams & Wilkins.