Preoperative chemoradiation in locally advanced pancreatic carcinoma: A phase II study

Citation
Tb. Brunner et al., Preoperative chemoradiation in locally advanced pancreatic carcinoma: A phase II study, ONKOLOGIE, 23(5), 2000, pp. 436-442
Citations number
25
Categorie Soggetti
Oncology
Journal title
ONKOLOGIE
ISSN journal
0378584X → ACNP
Volume
23
Issue
5
Year of publication
2000
Pages
436 - 442
Database
ISI
SICI code
0378-584X(200010)23:5<436:PCILAP>2.0.ZU;2-R
Abstract
Background: Effectiveness and feasibility of preoperative chemoradiation (C RT) in locally advanced adenocarcinoma of the pancreas are evaluated. Mater ial and Methods: 29 eligible of 37 registered patients were treated. Sd-Con formal external radiotherapy was delivered with a 1.8-Gy single dose and a total dose of 50.4 Gy plus 5.4 Gy boost. Simultaneous chemotherapy consiste d of 5-fluorouracil and mitomycin C. Results: Among 27 completely treated p atients, 16 (59%) underwent surgery, 6 of them being irresectable intraoper atively. Ten patients (37%) had clear resection margins at Whipple's proced ure. Eleven patients were not considered for surgery (7 still irresectable at restaging, 3 distant metastases, 1 refusal of surgery). Toxicity was pre dominantly hematological (grade 3: 30%, grade 4: 7%); furthermore, there wa s nausea/vomiting (grade 3: 20%, grade 4: 0%). No patient died perioperativ ely. The tumor-related overall survival rate was better for resected patien ts than for nonresected patients (50% vs. 6%, 2-year survival, p=0.07), med ian overall survival was 9 months (median follow-up, 28 months). Conclusion s: Neoadjuvant CRT without significant acute toxicity produced a resectabil ity rate of 37% (all R0), which should be confirmed by randomized phase III studies.