Background: Effectiveness and feasibility of preoperative chemoradiation (C
RT) in locally advanced adenocarcinoma of the pancreas are evaluated. Mater
ial and Methods: 29 eligible of 37 registered patients were treated. Sd-Con
formal external radiotherapy was delivered with a 1.8-Gy single dose and a
total dose of 50.4 Gy plus 5.4 Gy boost. Simultaneous chemotherapy consiste
d of 5-fluorouracil and mitomycin C. Results: Among 27 completely treated p
atients, 16 (59%) underwent surgery, 6 of them being irresectable intraoper
atively. Ten patients (37%) had clear resection margins at Whipple's proced
ure. Eleven patients were not considered for surgery (7 still irresectable
at restaging, 3 distant metastases, 1 refusal of surgery). Toxicity was pre
dominantly hematological (grade 3: 30%, grade 4: 7%); furthermore, there wa
s nausea/vomiting (grade 3: 20%, grade 4: 0%). No patient died perioperativ
ely. The tumor-related overall survival rate was better for resected patien
ts than for nonresected patients (50% vs. 6%, 2-year survival, p=0.07), med
ian overall survival was 9 months (median follow-up, 28 months). Conclusion
s: Neoadjuvant CRT without significant acute toxicity produced a resectabil
ity rate of 37% (all R0), which should be confirmed by randomized phase III
studies.