Substituted guanidines: Introducing diversity in combinatorial chemistry

Authors
del Fresno, M El-Faham, A Carpino, LA Royo, M Albericio, F
Citation
M. Del Fresno et al., Substituted guanidines: Introducing diversity in combinatorial chemistry, ORG LETT, 2(23), 2000, pp. 3539-3542
Citations number
34
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
23
Year of publication
2000
Pages
3539 - 3542
Database
ISI
SICI code
1523-7060(20001116)2:23<3539:SGIDIC>2.0.ZU;2-6
Abstract
[GRAPHICS] The guanidine moiety is an important motif present in many biologically act ive compounds. Fully substituted guanidines are of key importance for the d evelopment of bioactive molecules. The present paper reports on an efficien t procedure for the direct solid phase conversion of amines to fully substi tuted guanidines under very mild conditions.