Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous Pictet-Spengler cyclization

Authors
Cesati, RR Katzenellenbogen, JA
Citation
Rr. Cesati et Ja. Katzenellenbogen, Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous Pictet-Spengler cyclization, ORG LETT, 2(23), 2000, pp. 3635-3638
Citations number
39
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
23
Year of publication
2000
Pages
3635 - 3638
Database
ISI
SICI code
1523-7060(20001116)2:23<3635:POHUAV>2.0.ZU;2-0
Abstract
[GRAPHICS] A vinylogous Pictet-Spengler cyclization has been carried out using activat ed aldehydes, ketones, and alkynes to prepare a variety of substituted hexa hydrobenzo[f]isoquinolines. A unique set of conditions was utilized to effe ct efficient cyclization with acid sensitive electrophiles.