Synthesis and deprotection of oligonucleotides under aprotic conditions

Authors
Chen, TQ Fu, JS Greenberg, MM
Citation
Tq. Chen et al., Synthesis and deprotection of oligonucleotides under aprotic conditions, ORG LETT, 2(23), 2000, pp. 3691-3694
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
23
Year of publication
2000
Pages
3691 - 3694
Database
ISI
SICI code
1523-7060(20001116)2:23<3691:SADOOU>2.0.ZU;2-#
Abstract
[GRAPHICS] Oligonucleotides containing an alkali labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted a cid and base. The development of a new family of exocyclic amine protecting groups is an integral component of this approach.