Molecular pathology and molecular pharmacology of osteosarcoma

Citation
M. Ladanyi et R. Gorlick, Molecular pathology and molecular pharmacology of osteosarcoma, PEDIAT PATH, 19(5), 2000, pp. 391-413
Citations number
149
Categorie Soggetti
Pediatrics
Journal title
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
ISSN journal
15227952 → ACNP
Volume
19
Issue
5
Year of publication
2000
Pages
391 - 413
Database
ISI
SICI code
1522-7952(200009)19:5<391:MPAMPO>2.0.ZU;2-H
Abstract
Abnormalities of many tumor suppressor genes and oncogenes have been descri bed in osteosarcoma, but separating early or primary from secondary or late genetic lesions has been difficult. Among early lesions, inactivation of b oth the P53 and RB pathways appears to be a central and perhaps necessary e vent in osteosarcomagenesis. We propose a working model for the molecular p athology of osteosarcoma and we review the numerous published studies exami ning the association of various molecular features with either advanced pre sentation, poor chemotherapy response or decreased patient survival.