Objective. The economic impact of routine vaccination of preschool children
with inactivated influenza vaccine was investigated.
Design. A decision analysis was performed using data from the literature. D
irect and indirect costs of each vaccination strategy were calculated and c
ompared with a strategy of not vaccinating.
Setting. Two settings were evaluated: a setting in which vaccination was av
ailable during flexible hours and a setting in which vaccination was availa
ble only during usual work hours (8:00 am-5:00 pm).
Results. Vaccination resulted in a net cost savings in both settings. The n
et savings per vaccine recipient were $21.28 in the flexible setting and $1
.20 in the restricted setting. Although the analysis was performed for the
inactivated vaccine, sensitivity analysis showed that the nasal vaccine cou
ld also result in a net cost savings depending on the price of the cold-ada
pted vaccine when it is licensed.
Conclusion. Vaccinating preschool children is economically advantageous. Se
rious consideration should be given to recommending vaccination in this age
group.