Synthesis and reactions of some new heterocyclic compounds containing thieno[2,3-(c)under-bar] pyridazine moiety

Authors
Citation
Sm. Radwan, Synthesis and reactions of some new heterocyclic compounds containing thieno[2,3-(c)under-bar] pyridazine moiety, PHOSPHOR SU, 163, 2000, pp. 153-169
Citations number
8
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
163
Year of publication
2000
Pages
153 - 169
Database
ISI
SICI code
1042-6507(2000)163:<153:SAROSN>2.0.ZU;2-P
Abstract
Saponification of ethyl 3-amino-4,5-diphenylthieno[2,3-(c) under bar ]pyrid azine-2-carboxyate (1) with alcoholic sodium hydroxide, followed by acidifi cation, afforded the corresponding acid 2. Also, reaction of 1 with ethanol amine and formamide, respectively, gave compounds 5 and 6. Compound 2 react s with orthophosphoric acid under different conditions to give some new thi eno[2,3-(c) under bar] pyridazine derivatives 3 and 4, which were subjected to reactions to produce compounds 7-18. Furtheremore, compounds 5 and 6 we re used to synthesize some substituted pyrimido[4',5':4,5]-thieno[2,3-(c) u nder bar ]pyridazine derivatives 21-30.