Sm. Radwan, Synthesis and reactions of some new heterocyclic compounds containing thieno[2,3-(c)under-bar] pyridazine moiety, PHOSPHOR SU, 163, 2000, pp. 153-169
Citations number
8
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Saponification of ethyl 3-amino-4,5-diphenylthieno[2,3-(c) under bar ]pyrid
azine-2-carboxyate (1) with alcoholic sodium hydroxide, followed by acidifi
cation, afforded the corresponding acid 2. Also, reaction of 1 with ethanol
amine and formamide, respectively, gave compounds 5 and 6. Compound 2 react
s with orthophosphoric acid under different conditions to give some new thi
eno[2,3-(c) under bar] pyridazine derivatives 3 and 4, which were subjected
to reactions to produce compounds 7-18. Furtheremore, compounds 5 and 6 we
re used to synthesize some substituted pyrimido[4',5':4,5]-thieno[2,3-(c) u
nder bar ]pyridazine derivatives 21-30.