New phenylfluorenyl based linkers for solid phase synthesis

Authors
Bleicher, KH Lutz, C Wuthrich, Y
Citation
Kh. Bleicher et al., New phenylfluorenyl based linkers for solid phase synthesis, TETRAHEDR L, 41(47), 2000, pp. 9037-9042
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
47
Year of publication
2000
Pages
9037 - 9042
Database
ISI
SICI code
0040-4039(20001118)41:47<9037:NPBLFS>2.0.ZU;2-G
Abstract
The synthesis of 9-(4-hydroxyphenyl)-9-H-fluoren-9-ol and 5-(4-(9-hydroxy-9 H-fluoren-9-yl)-phenoxy) pentanoic acid and their applications as new linke rs for solid phase synthesis is reported. These supports show higher acid s tability compared to standard trityl resins. Carboxylic acids and amines ar e immobilized and cleaved off after further modifications. TFA treatment re leases the products in high yield and excellent purity. (C) 2000 Elsevier S cience Ltd. All rights reserved.