M. Antopolsky et A. Azhayev, Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioateconjugates employing Fmoc peptide chemistry, TETRAHEDR L, 41(47), 2000, pp. 9113-9117
A straightforward stepwise method for the preparation of peptide-oligonucle
otide phosphorothioate conjugates, was developed, based on the highly effic
ient Fmoc peptide solid phase synthesis, followed by oligonucleotide phosph
orothiate chain assembly. The three conjugates synthesized contained 15- or
17-mer oligonucleotide phosphorothioates and 10- or 16-mer peptides, incor
porating two or three arginine residues. (C) 2000 Elsevier Science Ltd. All
rights reserved.