Synthesis of symmetrical dimeric N,N '-linked peptides on solid support byolefin metathesis

Authors
Conde-Frieboes, K Andersen, S Breinholt, J
Citation
K. Conde-frieboes et al., Synthesis of symmetrical dimeric N,N '-linked peptides on solid support byolefin metathesis, TETRAHEDR L, 41(47), 2000, pp. 9153-9156
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
47
Year of publication
2000
Pages
9153 - 9156
Database
ISI
SICI code
0040-4039(20001118)41:47<9153:SOSDN'>2.0.ZU;2-K
Abstract
A method has been developed for the synthesis of dimeric ligands of biologi cal relevance on solid support using olefin metathesis as a key step. With the ruthenium catalyst used, the size of the peptide fragment did not influ ence the reaction. If the double bond involved was separated by at least si milar to2 methylene groups from an amide group, products of good purity cou ld be recovered. (C) 2000 Elsevier Science Ltd. All rights reserved.