Macrolactonization of hydroxy acids using a polymer bound carbodiimide

Authors
Keck, GE Sanchez, C Wager, CA
Citation
Ge. Keck et al., Macrolactonization of hydroxy acids using a polymer bound carbodiimide, TETRAHEDR L, 41(45), 2000, pp. 8673-8676
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
45
Year of publication
2000
Pages
8673 - 8676
Database
ISI
SICI code
0040-4039(20001104)41:45<8673:MOHAUA>2.0.ZU;2-K
Abstract
An efficient macrolactonization procedure using a polymer bound carbodiimid e is described. The procedure uses the polymer supported reagent as a repla cement for dicyclohexylcarbodiimide and thus considerably simplifies the wo rkup for such reactions. Partitioning between macrolactone and diolide is s hown to depend upon the equivalents of reagent used in cases for which lact onization is difficult. (C) 2000 Published by Elsevier Science Ltd.