Isolation and structure elucidation of coleophomones A and B, novel inhibitors of bacterial cell wall transglycosylase

Authors
Wilson, KE Tsou, NN Guan, ZQ Ruby, CL Pelaez, F Gorrochategui, J Vicente, F Onishi, HR
Citation
Ke. Wilson et al., Isolation and structure elucidation of coleophomones A and B, novel inhibitors of bacterial cell wall transglycosylase, TETRAHEDR L, 41(45), 2000, pp. 8705-8709
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
45
Year of publication
2000
Pages
8705 - 8709
Database
ISI
SICI code
0040-4039(20001104)41:45<8705:IASEOC>2.0.ZU;2-O
Abstract
The discovery, structure and absolute stereochemistry of coleophomones A an d B are described, two structurally novel natural products that inhibit bac terial transglycosylase activity. Coleophomone A represents a new ring syst em, containing a highly condensed structure which undergoes a reversible re troaldol reaction to form coleophomone B. (C) 2000 Elsevier Science Ltd. Al l rights reserved.