The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-one as novel protein kinase C modulators

Authors
Zhao, LY Qiao, LX Rong, SB Kozikowski, AP
Citation
Ly. Zhao et al., The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-one as novel protein kinase C modulators, TETRAHEDR L, 41(45), 2000, pp. 8711-8715
Citations number
31
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
45
Year of publication
2000
Pages
8711 - 8715
Database
ISI
SICI code
0040-4039(20001104)41:45<8711:TSOS(A>2.0.ZU;2-R
Abstract
The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-one s from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) i sopropoxide and sodium cyanoborohydride, followed by the cyclization to ure a using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd. All rights reserved.