Bis-Suzuki reactions of 2,3-dihaloindoles. A convenient synthesis of 2,3-diarylindoles

Authors
Liu, YB Gribble, GW
Citation
Yb. Liu et Gw. Gribble, Bis-Suzuki reactions of 2,3-dihaloindoles. A convenient synthesis of 2,3-diarylindoles, TETRAHEDR L, 41(45), 2000, pp. 8717-8721
Citations number
44
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
45
Year of publication
2000
Pages
8717 - 8721
Database
ISI
SICI code
0040-4039(20001104)41:45<8717:BRO2AC>2.0.ZU;2-T
Abstract
A convenient, one-pot synthesis of 2,3-diarylindoles 4 is described via a b is-Suzuki palladium-catalyzed cross coupling of 2,3-dihalo-1-(phenylsulfony l)indoles 1 with arylboronic acids 2, followed by cleavage of the N-protect ing group to give 4. The anti-inflammatory drug indoxole (4c) is prepared i n high yield. (C) 2000 Elsevier Science Ltd. All rights reserved.