Lipase-catalyzed kinetic resolution of racemic seven-membered substituted lactones

Authors
Shioji, K Matsuo, A Okuma, K Nakamura, K Ohno, A
Citation
K. Shioji et al., Lipase-catalyzed kinetic resolution of racemic seven-membered substituted lactones, TETRAHEDR L, 41(45), 2000, pp. 8799-8802
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
45
Year of publication
2000
Pages
8799 - 8802
Database
ISI
SICI code
0040-4039(20001104)41:45<8799:LKRORS>2.0.ZU;2-S
Abstract
Optically active 3-, 4-, 5-, or 6-methyl substituted seven-membered lactone s were prepared by Candida antarctica lipase (CAL)-catalyzed kinetic resolu tion of the racemic lactones. Among these lactones, only in the case of 5-m ethylhexanolide (R)-isomer reacts faster than the other enantiomer, while t he rest of lactones show (S)-selectivity. (C) 2000 Elsevier Science Ltd. Al l rights reserved.