Regioselective lipase acylation as a useful tool for separation and selective protection of beta-D-Gal(1 -> 4)-D-GlcNAc and beta-D-Gal(1 -> 3)-D-GlcNAc disaccharides

Authors
La Ferla, B Lay, L Russo, G Panza, L
Citation
B. La Ferla et al., Regioselective lipase acylation as a useful tool for separation and selective protection of beta-D-Gal(1 -> 4)-D-GlcNAc and beta-D-Gal(1 -> 3)-D-GlcNAc disaccharides, TETRAHEDR-A, 11(18), 2000, pp. 3647-3651
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
18
Year of publication
2000
Pages
3647 - 3651
Database
ISI
SICI code
0957-4166(20000922)11:18<3647:RLAAAU>2.0.ZU;2-D
Abstract
Supported lipase from Candida antarctica (Chirazyme((R))) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic e quivalents of beta-(D)-Gal(1 ->3)-(D)-GlcNAc and beta-(D)-Gal(1->4)-(D-)Glc NAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme tow ards 1 and 2 was also exploited for an easy separation of the mixture of th e two compounds obtained from a straightforward synthetic approach. (C) 200 0 Elsevier Science Ltd. All rights reserved.