IMMUNOSORBENT FOR IGG APHERESIS - AN IN-VITRO STUDY

We obtained anti-IgG Sepharose-an immunosorbent with sheep monospecifi c polyclonal antibodies against human IgG-for extracorporeal removal o f human IgG. Appropriate conditions for effective usage of the immunos orbent were chosen. Binding capacity and selectivity of anti-IgG Sepha rose were determined and compared with the corresponding properties of other sorbents for IgG apheresis; these properties appeared to be acc eptable for immunoapheresis procedures. Methods for therapeutic applic ation of anti-IgG Sepharose are described. Anti-IgG Sepharose is expec ted to be effective when used in immunoapheresis procedures for treatm ent of autoimmune diseases and for preparation of patients for organ t ransplantation. (C) 1997 Elsevier Science Ltd.