SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF NITROXANTHONES .2. ANTIMYCOBACTERIAL ACTIVITY

Authors
IBROM WGA SCHAPER KJ FRAHM AW
Citation
Wga. Ibrom et al., SYNTHESIS AND ANTIMYCOBACTERIAL ACTIVITY OF NITROXANTHONES .2. ANTIMYCOBACTERIAL ACTIVITY, Arzneimittel-Forschung, 47(6), 1997, pp. 767-773
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
47
Issue
6
Year of publication
1997
Pages
767 - 773
Database
ISI
SICI code
0004-4172(1997)47:6<767:SAAAON>2.0.ZU;2-7
Abstract
The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise inter pretation by means of the bacterial growth kinetics method. Nitroxanth ones with the 2,4-dinitrosubstitution pattern show activities beyond 1 mu g/ml.