SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF BETA-[(2-BENZIMIDAZOLYL)THIO]-BETA-BENZOYL STYRENE DERIVATIVES

In this study some new beta-[(2-benzimidazolyl)thio]-beta-benzoyl styr ene derivatives have been synthesized by reacting 2-(phenacetylthio)be nzimidazole and substituted benzaldehydes in piperidine / dry benzene. Structures were verified by microanalysis, IR and NMR spectral analys is. Antimicrobial activities of the compounds were investigated by the microdilution susceptibility test; Muller-Hinton Broth and Sabouraud Dextrose Broth were used for the determination of antibacterial and an tifungal activity. Test organisms: Staphylococcus aureus ATCC 29213 an d Enterococcus faecalis ATCC 29212 as Gram (+) bacteria, Escherichia c oli ATCC 25922 and Pseudomonas aeruginosa ATTC 27853 as Gram (-) bacte ria, and Candida albicans, Candida pseudotropicalis, Candida parapsilo sis and Candida stellatoidea as yeast-like fungi. All the compounds sh owed good antimicrobial effect, especially against gram (+) bacteria. Among the compounds tested eta-[(2-benzimidazolyl)thio]-beta-benzoyl-4 -chloro styrene (compound 9), beta-[(2-benzimidazolyl)thio]-beta-benzo yl-4-nitro styrene (compound 10) and (2-benzimidazolyl)thio]-beta-benz oyl-4-acetylamino styrene (compound 11) showed the most favorable acti vity.