Tm. Lee et al., Distension of urinary bladder induces exaggerated coronary constriction insmokers with early atherosclerosis, AM J P-HEAR, 279(6), 2000, pp. H2838-H2845
Citations number
50
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Distension of the urinary bladder causes an increase in efferent sympatheti
c activity, which can precipitate myocardial ischemia. Smoking has been sho
wn to modulate activities of afferent nerves from the distended urinary bla
dder and to impair endothelial function in response to sympathetic activati
on. To assess the effect of bladder distension on coronary dynamics in smok
ers, we measured epicardial and microvascular responses in 24 patients with
early atherosclerosis (< 50% diameter stenosis). Patients were classified
into habitual smokers (group 1, n = 14) and nonsmokers (group 2, n = 10). H
abitual smokers were randomized into two subgroups on the basis of the use
of doxazosin, as follows: subgroup 1A (n = 7), without administration of do
xazosin before catheterization; subgroup 1B (n = 7), with dosing doxazosin.
In response to bladder distension (mean intravesical pressure 21.5 mmHg),
bladder distension significantly decreased coronary diameter at the stenoti
c segments, coronary blood flow, and increased coronary resistance compared
with baseline values, in subgroup 1A patients. In subgroup 1B patients dur
ing bladder distension, coronary diameter, coronary blood flow, and coronar
y resistance did not show significant changes compared with baseline values
. There were significant differences of coronary diameter at the stenotic s
egments, coronary blood flow, and of changes of coronary vascular resistanc
e between subgroup 1A and group 2 during bladder distension, despite simila
r changes in rate-pressure product. The present study showed that urinary b
ladder distension caused an abnormal vasomotor response of epicardial vasoc
onstriction and a concomitant increased coronary resistance, which leads to
reduction in coronary blood flow in patients with early atherosclerosis. S
moking may further impair the response, implying that smoking has exaggerat
ed response to sympathetic stimulation of conduit and resistance vessels. T
he abnormal response was abolished by pretreated administration of doxazosi
n, suggesting that the involved mechanisms are related to <alpha>(1)-adreno
ceptors.