There are no previous reports concerning comorbidity of psychosis and
idiopathic familial restless legs syndrome (RLS). In the psychiatric l
iterature the concept ''Ekbom's syndrome'' has been equated with delus
ions of parasitosis and not to a paresthetic, organic disorder. Psycho
tic patients invariably receive the diagnosis of akathisia. We report
a family with genetic disposition to idiopathic RLS and psychotic illn
ess. Excellent short-term treatment effect of tramadol for idiopathic
RLS is reported for the first time. Four-limb actometry, a novel metho
d for diagnosing and measuring RLS and akathisia, is described. We sug
gest that the relationship of RLS, psychosis, and idiopathic or drug-i
nduced akathisia has been obscured by nosologic difficulties. RLS shou
ld be considered a diagnosis and treated even among psychotic patients
, although it may be rare. Tramadol may be useful in short-term treatm
ent of RLS.