Insulin desensitization with insulin lispro and an insulin pump in a 5-year-old child

Citation
Ss. Eapen et al., Insulin desensitization with insulin lispro and an insulin pump in a 5-year-old child, ANN ALLER A, 85(5), 2000, pp. 395-397
Citations number
12
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
ISSN journal
10811206 → ACNP
Volume
85
Issue
5
Year of publication
2000
Pages
395 - 397
Database
ISI
SICI code
1081-1206(200011)85:5<395:IDWILA>2.0.ZU;2-W
Abstract
Background and objective: Allergic reactions to insulin, though rare, can h ave serious consequences in children with type I diabetes mellitus. We repo rt a case of insulin allergy in a 5-year-old child in whom insulin desensit ization was accomplished using an insulin pump. Methods and results: A 5-year-old girl with insulin-dependent diabetes mell itus (IDDM) developed progressive reactions to insulin and was found to hav e positive intradermal skin tests to regular and NPH insulin. Addition of o ral antihistamine and co-administration of subcutaneous dexamethasone along with the insulin failed to control her symptoms. The patient was therefore hospitalized and desensitized to insulin using an insulin pump and insulin lispro. Conclusion: An insulin pump can be used for insulin desensitization in sele cted children. The slow constant infusion rate provided by the pump may be an ideal means of achieving insulin desensitization. In addition, insulin l ispro, a synthetic insulin analog, should be considered for use in insulin- allergic individuals.