Iron status in Danes 1994 II: Prevalence of iron deficiency and iron overload in 1319 Danish women aged 40-70 years. Influence of blood donation, alcohol intake and iron supplementation

Iron status, i.e. serum ferritin and haemoglobin (Hb) levels, was assessed in a population survey in 1994 (Dan-Monica 10) comprising 1319 Caucasian Da nish women in age cohorts of 40, 50, 60 and 70 years. In the entire series, ferritin levels increased significantly from 40 years to 60 years of age. The prevalence of small iron stores (ferritin 16-32 mug/l), depleted iron s tores (ferritin <16 <mu>g/l) and of iron deficiency anaemia (ferritin < 13 <mu>g/l and Hb < 121 g/l) decreased steadily with age. Blood donors (n=109) had lower ferritin levels than non-donors (P< 0.0001). Ferritin levels in donors were inversely correlated with the cumulated number of lifetime phle botomies (r (S)= - 0.25, P< 0.01). Ferritin levels in non-donors (n = 1208) were low in 40-year-old women (median 40 <mu>g/l) and increased to a media n of 95 mug/l in 60- and 70-year-old women (P< 0.0001). In non-donors 40 ye ars of age, the prevalence of small iron stores was 40.4%, the prevalence o f depleted iron stores 10.8% and the prevalence of iron deficiency anaemia 2.16%. The prevalence of iron overload (ferritin >300 mug/l) was 1.54%. Fer ritin levels in 60- and 70-year-old non-donors were correlated with the bod y mass index (r(S)=0.11, P=0.01). Ferritin levels in 50- to 60-year-old non -donors were correlated with alcohol intake (r(S)=0.23, P<0.0001). In the e ntire series, 37.5% of non-donors took supplemental ferrous iron (median 14 mg iron per day). Iron supplements had a significant positive influence on iron status in 40 year-old premenopausal non-donors but no effect in postm enopausal women or in donors. Non-donors (n = 170) treated with acetylsalic ylic acid had lower ferritin levels (median 55 <mu>g/l) than non-treated (n = 1038; median 75 mug/l) (P<0.0001). Compared with the Dan-Monica 1 iron s tatus survey in 1984, the prevalence of iron deficiency and iron deficiency anaemia was unchanged, whereas the prevalence of iron overload displayed a slight increase. The 1987 abolition of the mandatory iron fortification of flour apparently had no negative effect on iron status.