Pa. Gross et al., TIME TO EARLIEST PEAK SERUM ANTIBODY-RESPONSE TO INFLUENZA VACCINE INTHE ELDERLY, Clinical and diagnostic laboratory immunology, 4(4), 1997, pp. 491-492
The earliest time at which serum antibody levels peak following admini
stration of an influenza virus vaccine in elderly persons is not clear
ly defined. We compared the time intervals of 1 and 2 weeks after vacc
ination. A commercial trivalent vaccine containing the hemagglutinins
of influenza viruses A/Texas/36/91 (H1N1), A/Johannesburg/33/94 (H3N2)
, and B/Harbin/7/94 was used. The hemagglutination inhibition (HAI) an
tibody titers at 1 week after vaccination were significantly lower tha
n the HAI titers at 2 weeks postvaccination for all three vaccine comp
onents.