PRESENCE OF A NEUTRALIZING DOMAIN IN ISOLATES OF RUBELLA-VIRUS IN CORDOBA, ARGENTINA

Authors
CORDOBA P GRUTADAURIA SL CUFFINI C ZAPATA MT
Citation
P. Cordoba et al., PRESENCE OF A NEUTRALIZING DOMAIN IN ISOLATES OF RUBELLA-VIRUS IN CORDOBA, ARGENTINA, Clinical and diagnostic laboratory immunology, 4(4), 1997, pp. 493-495
Citations number
22
Categorie Soggetti
Immunology,"Infectious Diseases","Medical Laboratory Technology",Microbiology
Journal title
Clinical and diagnostic laboratory immunology → ACNP
ISSN journal
1071412X
Volume
4
Issue
4
Year of publication
1997
Pages
493 - 495
Database
ISI
SICI code
1071-412X(1997)4:4<493:POANDI>2.0.ZU;2-A
Abstract
We studied the presence of a neutralizing epitope of rubella virus (RV ) in locally circulating strains in Cordoba, Argentina, using binding by the monoclonal antibody (MAb) H3. This epitope is contained in a se quence of the E1 glycoprotein (E1(208-239)) represented by the synthet ic peptide SP15. H3 MAb showed specific binding to SP15 by enzyme-link ed immunosorbent assay (ELISA). One wild-type postnatal isolate, four clones derived from this isolate, and one congenital isolate were reac tive with H3 by ELISA. These results suggest that the region of RV rep resented by SP15 is a domain present in locally circulating strains.