Pericentric inversion of the Y chromosome of infertile male

The authors report a case with pericentric inversion of the Y chromosome as sociated with asthenonecrozoospermia. The conventional karyotype was 46, X, inv (Y) (p11q11). Polymerase chain reaction (PCR) analysis revealed the de letion of DYZ3, DYS139, and RBM1. Three-color fluorescent in situ hybridiza tion (FISH) analysis of the sperm chromosomes showed normal ratio between X - and Y-bearing sperm. In this case, the frequencies of aneuploidy of the s perm are not significantly higher compared with those from the normal volun teers. Cytogenetic analysis is recommended when the patients with pericentr ic inversion of the Y chromosome are attending an infertility clinic.