The fertility and pregnancy outcomes of the patients who underwent preservative operation followed by adjuvant chemotherapy for malignant ovarian tumors

The fertility and pregnancy outcomes of the patients were studied, who prev iously underwent preservative operation for malignant tumors, including tho se of borderline malignancy, in our ward from 1981 to 1995. For each of the 9 patients, unilateral ovary was preserved, the range of their ages before operation was 10 to 28 years old, and histologically, 7 patients had tumor s derived from germ cells, and 2 had those from epithelial cells. As for cl inical stages according to the FIGO's criteria, 5, 1, 2 and 1 patients were in stage I, II, III and IV, respectively. The regimens of the combination chemotherapy for patients with germ cell tumors were PVB (cisplatin, vinbla stine and bleomycin), PEP (cisplatin, etopside and pepleomycin), PVP (cispl atin, vinblastine and pepleomycin), AVAC (doxorubicin, vincristine, actinom ycin-d and cyclophosphamide). Those for the patient with epithelial tumors were CAP (cyclophosphamide, doxorubicin and cisplatin), CP (cyclophosphamid e and cisplatin). Eight patients have been doing well, although 1 of them e xperienced recurrence and died. Amenorrheic periods of 2 to 12 months were noticed in 3 patients, although in all of them, ovulatory cycles recovered. Eight pregnancies were reported: 5 term delivery with normal babies, and o thers were preterm termination due to abruptio placenta with a baby of appr opriate for date, spontaneous abortion, and artificial termination. We supp ose that the combination chemotherapy applied for the patients in the prese nt study affected neither the fertility of the patients nor the outcomes of the pregnancies.